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KMID : 0378019840270010082
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New Medical Journal
1984 Volume.27 No. 1 p.82 ~ p.90
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The Role of High Density Lipoprotein Cholesterol in the Prevention of Hypertension and Cerebral Stroke
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Abstract
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Hypercholesterolemia is well known as a risk factor for the development of atherosclerotic vascular diseases. Recently the high density lipoprotein (HDL) was found to have antiathrogenic component but it is still on controversial. The HDL2-cholesterol, one of the major subfraction of HDL was proposed as the antiathrogenic component which directly inhibit the binding of low density lipoprotein to the target cell at receptor level.
To assess the possible preventive role of HDL and HDL2 subfraction in patients with hypertension and cerebral strokes, we studied with 76 patients with hypertension, 62 patients with cerebral infarction and 64 patients with cerebral hemorrhage.
Following results were obtained.
1. In both group of hypertension and cerebral infarction, the HDL-cholesterol was not changed but the total cholesterol, VLDL-cholesterol, LDL-cholesterol and total cholesterol/HDL cholesterol ratio was significantly higher than control group.
2. In patients with cerebral hemorrhage, the HDL-cholesterol was significantly higher than control group and total cholesterol, LDL-cholesterol and total cholesterol/HDL-cholesterol ratio was also higher than control group.
3. The level of HDL2-cholesterol in patients with cerebral strokes was significantly lower than control group but no significant difference was found in hypertensive patients.
Above results suggest that the pathogenesis of hypertension, cerebral infarction and cerebral hemorrhage can not be understand with common abnormalities of lipoprotein metabolism and more additional factors must be involved.
The preventive role of HDL-cholesterol was only accepted in cerebral infarction and the suggested antiatherogenic component was HDL2-cholesterol.
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KEYWORD
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